Association mapping of gene factors and sociodemographics for pre-disposition
to schizophrenia
 
   Lead Investigator:    Jade Hind
   Institution      :    Liverpool John Moores University
   E-Mail           :    j.hind@2012.ljmu.ac.uk
   Proposal ID      :    697



   Proposal Description:
   The objective of the proposed study is to investigate the associations between    individual genetic markers (SNPs) or groups of markers and particular symptoms    experienced by patient with schizophrenia or AD. This requires the GAIN           assessment data outlining quantitative clinical endophenotype observations,       initially concentrating on depression, mania and hallucination. The proposed      methodology starts with a GWAS to obtain SNPs which are indicative of             susceptibility to schizophrenia or AD. Exploratory and confirmatory factor        analysis will be conducted to structure the quantitative traits in relation to    the diagnosed symptoms including in the model also contextual variables such as   age and sex. The case-control association analysis will use exploratory           clustering models as well as more structure finding models such as conditional    independence maps, for which we have scalable software. This will then be         followed by a case only design investigating the variants in biomarkers           concerning particular symptoms along with exploring the possible effects of       external factors in the aggravation or onset of schizophrenia or AD validated     using control data.'